This paper addresses an important yet neglected existential issue sometimes faced by persons with bipolar disorder BD : confusion about the extent to which what one is like is influenced by BD. Although such confusion is common in psychiatric illnesses, BD raises idiosyncratic difficulties due to its intricate interactions with personality, cognition and behavior. The fluctuating mood phases of BD can generate inconsistency in one's self-experience and sense of self. One way to resolve this confusion would be to coherently account for BD within one's overall self-concept. To facilitate this task, this paper introduces a heuristic taxonomy of different relationships wherein BD can be viewed in light of self-related beliefs. As the individual presentation of BD varies extensively, the type of relationship one feels holds true depends on one's personal experience of bipolar disorder and dating and living with the disorder. These relationships act as an organizing framework for one's self-related beliefs about how to account for the effects of BD on personality, behavior, cognitive patterns and other self-expressions. Know thyself : bipolar disorder and self-concept. Dateien Zu diesem Dokument gibt es keine Dateien. Datum Autor:innen Carls-Diamante, Sidney. ISSN der Zeitschrift. Electronic ISSN. Bibliografische Daten. URI zitierfähiger Link. Internationale Patentnummer. Angaben zur Forschungsförderung. Open Access-Veröffentlichung. Sammlungen Philosophie Zukunftskolleg. Core Facility der Universität Konstanz. Gesperrt bis. Titel in einer weiteren Sprache. Publikationstyp Bipolar disorder and dating. Publikationsstatus Published. Erschienen in Philosophical Explorations. ISSN Available under: doi: Zusammenfassung This paper addresses an important yet neglected existential issue sometimes faced by persons with bipolar disorder BD : confusion about the extent to which what one is like is influenced by BD. Zusammenfassung in einer weiteren Sprache. Fachgebiet DDC Philosophie. Zitieren ISO CARLS-DIAMANTE, Sidney, In: Philosophical Explorations. Interner Vermerk. URL der Originalveröffentl. Prüfdatum der URL. Prüfungsdatum der Dissertation. Kommentar zur Publikation. Corresponding Authors der Uni Konstanz vorhanden.
Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, , Israel. Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H. Brain Res. Update on GPCR-based targets for the development of novel antidepressants. Article PubMed CAS Google Scholar Selten M, van Bokhoven H, Nadif Kasri N.
Causes and diagnosis
Here we show that the disease-associated ADCY2 missense mutation diminishes the enzyme´s capacity to generate the second messenger 3',5'-cylic. meter und IRI-Ska-. PDF | Deficits of theory of mind and empathy have been reported in bipolar disorder and schizophrenia Daten, MASC-Para-. We investigated the relationship between personality profiles and the prediction of longterm illness severity in patients with bipolar disorder (BD). Whether you have bipolar disorder or are dating someone with the condition, learn what you can do to maintain a healthy and fulfilling.Address Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie des Universitätsklinikums Margarete-Höppel-Platz 1 Würzburg Deutschland. Behavioral testing started between day 10 and day 12, throughout which LiCl was continuously administered. Article PubMed PubMed Central CAS Google Scholar Perry W, Minassian A, Henry B, Kincaid M, Young JW, Geyer MA. PubMed CAS Google Scholar Persson E, Bak H, Olsen OH. Corresponding Authors der Uni Konstanz vorhanden. PS performed cell culture and behavioral experiments, analyzed and interpreted data and wrote the first draft of the manuscript. Genome-wide association study identifies 30 loci associated with bipolar disorder. J Biol Chem. Department of Neuroscience, Karolinska Institutet, Stockholm, , Sweden. Each dot represents an individual cell. Article PubMed CAS Google Scholar Moreno-Mateos MA, Vejnar CE, Beaudoin JD, Fernandez JP, Mis EK, Khokha MK, et al. Transl Psychiatry. L mice also displayed deficits in accomplishing spatial learning and memory tasks, which were additionally reflected by reduced hippocampal LTP indicating alterations in synaptic plasticity induced by the disease-associated ADCY2 variant. The gene ontology enrichment analysis of DEGs using the KEGG database yielded the highest number of affected processes and pathways in glutamatergic CA1 neurons. In contrast, ADCYs, which are essential for the generation of the second messenger cAMP, have largely been ignored [ 21 ]. The altered frequency of mEPSCs and mIPSCs suggest alterations in synaptic release probabilities. Scientific Core Unit Electrophysiology, Max Planck Institute of Psychiatry, , Munich, Germany. Hum Mol Genet. Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes. Trends Pharmacol Sci. On the other hand, the assessment of endogenous ADCY2-dependent cAMP levels or respective alterations caused by the VL mutation is technically not practicable as the measurements will be masked by a high background caused by the other members of the ADCY family which cannot be completely blocked. Ethics approval All animal experiments were conducted with the approval of and in accordance with the Guide of the Care and Use of Laboratory Animals of the Government of Upper Bavaria, Germany. The sample size was chosen such that with a type 1 error of 0. Among other family members, however, it is only found in its closest relative ADCY7 Fig. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. DM and ME performed electrophysiological recordings. Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase. CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress Article 15 February Article PubMed Google Scholar Fabbri C. The Role of Genetics in Bipolar Disorder. Zitieren ISO CARLS-DIAMANTE, Sidney, Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landen M, et al. To facilitate this task, this paper introduces a heuristic taxonomy of different relationships wherein BD can be viewed in light of self-related beliefs. Some potential biomarkers for bipolar disorder include:. This suggests that inflammation may play a role in the development of the illness.
